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SCAPING Inflammation!
By Krystal Villalobos-Ayala Endothelial cells (EC) respond to a plethora of external stimuli (i.e. infection,inflammatory cytokines) and with constant activation of EC can lead to atherosclerosis andrecruitment of inflammatory immune cells. The relationship between inflammation andcholesterol homeostasis has only been studied in atherosclerosis, however, the mechanism ofaction has not been elucidated.Fowler et al, show the […]
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Elucidating histone deacetylase 3 and its role in CD4 + T cell activation
By Sara Leahey CD4 + T cells undergo a metabolic shift after activation, increasing cellular processes that make blasting and proliferation possible. A Class I histone deacetylase called histone deacetylase 3 (HDAC3) represses gene expression through the deacetylation of lysine residues on histones 3 and 4. HDAC3 has been shown to be a key regulator […]
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How to constructively critique a manuscript: Literature Review
by El-Kenawi, A.* Objectives: To teach graduate students how to come with a constructive peer-review for manuscripts. To teach students how to write a lay abstract or a highlight for a published paper. Plan: Research Article Assignments: *I give this class as a part of Cancer Immunotherapy, Immunology PhD Program.
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The Fantastic BH4 matters in T cells
Tetrahydrobiopterin (BH4) is an essential cofactor in the biosynthesis of molecules regulating neurotransmission and vascular tone. In a recent publication, Cronin and colleagues discovered a novel role of BH4 in regulating T cell immunity. Cells generate BH4 through de novo synthesis catalyzed mainly by GTP cyclohydrolase I (GCH1) and sepiapterin reductase (SPR). Through modulating the […]
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